Tasigna 150mg

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Tasigna 150mg (nilotinib) is indicated for the treatment of adult and pediatric patients greater than or equal to 1 year of age with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in chronic phase.

Tasigna 150mg is indicated for the treatment of adult patients with chronic phase and accelerated phase Philadelphia chromosome-positive chronic myelogenous leukemia (Ph+ CML) resistant or intolerant to prior therapy that included imatinib.

Tasigna 150mg is indicated for the treatment of pediatric patients greater than or equal to 1 year of age with chronic phase Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) with resistance or intolerance to prior tyrosine-kinase inhibitor (TKI) therapy.

What is Tasigna 150mg Capsule?

Tasigna is a prescription medicine used to treat:

• adults and children who have been newly diagnosed with a certain type of leukemia called Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in chronic phase.
• adults with chronic phase Ph+ CML or accelerated phase Ph+ CML who:
• are no longer benefiting from other treatments, including imatinib (Gleevec), or
• have taken other treatments, including imatinib (Gleevec), and cannot tolerate them.
  • children with chronic phase Ph+ CML who:
  • are no longer benefiting from treatment with a tyrosine-kinase inhibitor medicine, or
  • have taken a tyrosine-kinase inhibitor medicine and cannot tolerate it.

It is not known if Tasigna is safe and effective in children younger than 1 year of age with newly diagnosed, resistant, or intolerant Ph+ CML in the chronic phase.

The long-term effects of treating children with Tasigna for a long period of time are not known.

How To Take Tasigna 150mg Capsule?

Before you start the treatment, read any printed information you have been given by your doctor and the printed manufacturer’s leaflet from inside the pack of capsules. These will give you more information about nilotinib and will provide a full list of the side-effects which you may experience from taking it.

Nilotinib will be prescribed for you by a specialist doctor who is experienced in treating your condition. It is important that you take the capsules exactly as you are told to. It is usual to take two capsules twice daily (morning and evening), although your dose may be different from this. There are two strengths of capsule available (150 mg and 200 mg) – you will be given the strength that is most suitable for your condition. The directions for taking the capsules will be printed on the label of the pack to remind you what your doctor has told you to do, but if you have any concerns or questions, you should contact your doctor or hospital clinic for further advice.

Swallow the capsules with a full glass of water. Do not chew the capsules. If you have difficulties swallowing capsules, you can mix the content of each capsule with a teaspoon of apple sauce (puréed apple). Swallow the mixture straight away. Do not use more than one teaspoon of apple sauce per capsule, and do not mix nilotinib with any other foods.

You should take the capsules when your stomach is empty of food, which means taking your doses an hour before a meal or waiting until two hours afterward. This is because food interferes with the way your body absorbs nilotinib and may increase the risk of harmful effects.

Do not drink grapefruit juice while you are on nilotinib. This is because a chemical in grapefruit juice can interfere with the amount of nilotinib in your bloodstream.

If you forget to take a dose, make sure that you remember to take your next dose when it is due. Do not take two doses together to make up for a missed dose.

Side Effects of Tasigna 150mg

• nausea
• rash
• headache
• tiredness
• itching
• vomiting
• diarrhea
• cough
• constipation
• muscle and joint pain
• runny or stuffy nose, sneezing, sore throat
• fever
• night sweats

Warning of Tasigna 150mg

Before taking nilotinib, tell your doctor or pharmacist if you are allergic to it, or to lactose/galactose; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, pancreatitis, heart disease (such as coronary artery disease, chest pain, heart attack), high blood pressure, high cholesterol, diabetes, stroke (including “mini-strokes” or transient ischemic attacks), blood circulation disease (peripheral arterial disease), blood vessel disease (hardening of the arteries/atherosclerosis), stomach surgery (such as gastrectomy).

The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using nilotinib, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).

Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/”water pills”) or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using nilotinib safely.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Do not have immunizations/vaccinations without the consent of your doctor. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose).

To lower the chance of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports.

This medication may affect a child’s bone growth and development. Consult the doctor or pharmacist for more details.

Older adults may be more sensitive to the side effects of this drug, especially QT prolongation (see above).

Tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while using nilotinib. Nilotinib may harm an unborn baby. Ask about reliable forms of birth control while using this medication and for 14 days after stopping treatment. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication.

It is not known whether this drug passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this drug and for 14 days after stopping treatment is not recommended. Consult your doctor before breast-feeding.

Precaution of Tasigna 150mg

• have heart problems
• have had a stroke or other problems due to decreased blood flow to the brain
• have problems with decreased blood flow to your legs
• have irregular heartbeat
• have QTc prolongation or a family history of it
• have liver problems
• have had pancreatitis
• have low blood levels of potassium or magnesium in your blood
• have a severe problem with lactose (milk sugar) or other sugars. Tasigna capsules contain lactose. Most people who have mild or moderate lactose intolerance can take Tasigna.
• have bleeding problems
• had a surgical procedure involving the removal of the entire stomach (total gastrectomy)
• are pregnant or plan to become pregnant. Tasigna can harm your unborn baby. Tell your healthcare provider right away if you are pregnant, or if you become pregnant during treatment with Tasigna.

Uses of Tasigna 150mg

Tasigna 150mg Capsule is used in the treatment of blood cancer (Chronic myeloid leukemia). It is used in patients whose disease could not be treated with other medications for leukemia or who cannot take these medications because of side effects.

Storage of Tasigna 150mg

Keep all medicines out of the reach and sight of children.

Store in a cool, dry place, away from direct heat and light.

Please return any unused or unwanted capsules to your clinic or pharmacy to destroy.

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