Lopimune Tablets

1. Buy Lopimune Tablets Online

Lopinavir and Ritonavir Tablets (Generic Kaletra) is an HIV-1 protease inhibitor which is used in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults and pediatric patients 14 days and older.

Lopimune tablets, the generic version of Kaletra are manufactured by Cipla Ltd. in the strengths of 250 mg (200 mg of Lopinavir and 50 mg of Ritonavir). We also have in stock Generic Atazanavir (Atavir Capsules) which is also used in combination with other medicines to treat the same indications.

2. How To Lopimune Work?

Lopimune tablets 200/50mg contain lopinavir and ritonavir, which are both inhibitors of HIV protease and are only effective against RNA viruses (retroviruses) like Human Immunodeficiency Virus (HIV).

Retroviruses convert RNA to DNA, by the action of the viral-specific enzyme reverse transcriptase (RT). The viral DNA is then integrated into the DNA of infected immune cells so that the virus can replicate.

Most of the antiviral activity of Lopimune is due to lopinavir, which is a potent inhibitor of HIV protease, and prevents cleavage of the Gag-Pol polyprotein, an important protein in the development of active virus. The viral protease enzyme cleaves (breaks down) the Gag-Pol polyprotein during the final stages of the replication cycle so that a fully active mature virus can be released to infect new cells.

Inhibition of protease cleavage by Lopimune results in the production of immature, non-infectious viral particles. Ritonavir in Lopimune tablets 200/50mg is included in the combination, not as a protease inhibitor but because it inhibits the CYP3A-mediated metabolism (breakdown in the liver) of lopinavir, thereby increasing the plasma levels of lopinavir so that lopinavir can be used at a lower dose.

Lopimune tablets are used in combination with other retroviral that have a different mechanism of action, like emtricitabine and tenofovir, both nucleoside reverse transcriptase inhibitor (NRTI) that work by blocking the action of RT, inhibiting viral replication.

The combined action of lopinavir and ritonavir in Lopimune tablets 200/50mg, in conjunction with other retroviral drugs, inhibits the production of active HIV so that the viral load (amount of virus) is reduced.

Lopimune tablets slow down the replication of HIV within your body but does not kill the virus already incorporated in the CD4+ cells or prevent the spread of the infection to others.

3. What is Lopimune Tablets?

Lopinavir and Ritonavir are antiretroviral agents that fall into the category of drugs known as protease inhibitors.

Both the drugs interfere with the virus reproduction to fight HIV or human immunodeficiency virus. The medication does not cure AIDS or destroy the virus.

It only helps in preventing further damage by slowing down the progression of the disease. Also, the combination drug is not capable of reducing the risk of passing the infections on to others.

A sufferer is still able to transfer the virus through sexual contact, sharing needles, or by blood transfer. Therefore, it is recommended to use precautionary measures to prevent passing HIV on to others.

4. Drug interaction of Lopimune

Drugs that cause a serious reaction with Lopimune: benzodiazepines like midazolam, PDE5 inhibitors like sildenafil for erectile dysfunction, statin drugs atorvastatin like for high cholesterol, salmeterol for asthma, ergot drugs like ergotamine for migraine headaches, cisapride for gastric reflux, the antipsychotic pimozide

Drugs that affect Lopimune: anticonvulsants like phenytoin and carbamazepine, the antibiotic rifampicin, corticosteroids like dexamethasone, the herbal product St Johns wort,

Drugs that are affected by Lopimune: other retrovirals like zidovudine and saquinavir, antiarrhythmics like amiodarone, anticancer agents like vincristine, the anticoagulant warfarin, anticonvulsants like carbamazepine, analgesics like fentanyl, digoxin for heart failure, the antidepressants trazodone and bupropion, anticonvulsants like phenytoin and carbamazepine, antifungals like ketoconazole, the antibiotic clarithromycin, benzodiazepines like midazolam, calcium channel blockers like nifedipine, the antipsychotic blonanserin, PDE5 inhibitors like sildenafil for erectile dysfunction, statin drugs atorvastatin like for high cholesterol, salmeterol for asthma, contraceptives like Ethinyl estradiol

5. Side Effects of Lopimune

• Weakness
• Insomnia
• Headache
• Pancreatitis
• Diarrhea
• Hepatitis
• Stevens-Johnson syndrome
• Abdominal pain
• Heart block
• Nausea
• Erythema multiform
• Rash
• Toxic epidermal necrolysis

6. Warning And Precaution of Lopimune Tablets

are allergic to lopinavir and ritonavir or any ingredients in Lopimune

are pregnant or are breastfeeding

have a particular heart condition called long QT syndrome, underlying structural heart disease, preexisting conduction system abnormalities, ischemic heart disease or cardiomyopathies

have severe liver disease like hepatitis or cirrhosis

have the blood condition hemophilia, without discussion with your doctor as Lopimune can cause increased bleeding

are taking medicines that interact with Lopimune, including: other retrovirals like zidovudine and saquinavir, antiarrhythmics like amiodarone, anticancer agents like vincristine, the anticoagulant warfarin, anticonvulsants like carbamazepine, analgesics like fentanyl, digoxin for heart failure, the antidepressants trazodone corticosteroids like dexamethasone, the antipsychotic blonanserin, PDE5 inhibitors like sildenafil for erectile dysfunction, ergot drugs like ergotamine for migraine headaches, the herbal product, cisapride for gastric reflux, the antipsychotic pimozide

7. Lopimune Dosage

Lopimune tablets can be taken with or without food. The tablets should be swallowed whole and not chewed, broken, or crushed. The dose of Lopimune tablets is as follows:

Adult Patients:

Lopimune tablets 400/100 mg (given as two 200/50 mg tablets) twice a day. Lopimune tablets 800/200 mg (given as four 200/50 mg tablets) once a day in patients with less than three lopinavir resistance-associated substitutions.

Once-daily administration of Lopimune is not recommended for adult patients with three or more of the following Lopinavir resistance-associated substitutions.

Lopinavir and Ritonavir tablets must not be administered once daily in combination with carbamazepine, phenobarbital, or phenytoin

Concomitant Therapy: Efavirenz, Nevirapine, or Nelfinavir

Lopinavir and Ritonavir tablets should not be administered as a once-daily regimen in combination with Efavirenz, Nevirapine, Or Nelfinavir.

An increase in dosage is recommended for all patients who use Lopimune tablets. The recommended dose of Lopimune tablets is 500/125 mg (such as two 200/50 tablets and one 100/25 mg tablet) twice daily in combination with Efavirenz, Nevirapine, Or Nelfinavir.

8. Uses of Lopimune

Lopimune tablets 200/50mg are a fixed-dose combination treatment for Human Immunodeficiency Virus (HIV) infection in adults over and children over 6 months.

Lopimune tablets200/50mg are used in combination with other medications that have a different mechanism of action to the components in Lopimune and are used to treat patients with HIV infection who have either already received treatment with other medications for HIV or as first-line therapy for treatment-inexperienced patients.

HIV impairs the immune system by attacking specific immune cells called CD4+ cells that are involved in fighting infection and this can lead to opportunistic life-threatening infection (infections that would not normally be harmful); also if too many CD4+ cells are destroyed this can result in acquired immune deficiency syndrome (AIDS).

Lopimune tablets prevent or slow down the ability of HIV to replicate and spread, which keeps the amount virus down to a low level and this results in an increase in CD4+ cell numbers so that the immune system can recover, reducing the risk of disease progression.

9. Storage of Lopimune

You should store your Lopimune tablets 200/50mg below 30°C in a cool dry place.

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